Improving the health of women, infants and families requires innovation paired with integrating evidence-based practice into care. The CMIH programs cross the reproductive continuum from preconception care through prenatal services, labor and delivery and quality postpartum care. Our current work includes two major studies to learn more about the needs of new mothers. We have a statewide initiative funded by the Duke Endowment to prevent preterm birth. Our team has provided leadership for many years on implementing 17P for recurring preterm birth prevention and tobacco cessation for pregnant and postpartum women. We have also launched a regional coalition that brings together leaders from across the South to work on the challenging issue of women’s health equity. And we are NOT done! We are constantly seeking new partnerships to challenge ourselves to think outside of the box and create real change for North Carolina’s women and infants.