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Collaborative for Maternal & Infant Health
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NICU Guidelines

NICU Guidelines

The UNC Newborn Critical Care Center (NCCC) guidelines are intended to assist providers with the clinical management of patients in the neonatal intensive care unit.

These guidelines serve as reference guides and are provided only to assist providers make clinical decisions regarding the management of patients. These guidelines do not establish a standard of care and do not substitute for the individual professional judgment necessary for each specific clinical presentation.

The ultimate judgment regarding the management of a specific patient must be made by the provider and the patient, taking into account such factors as characteristics of the individual patient, healthcare resources, and regional experience with diagnostic and therapeutic modalities. These guidelines are reviewed and updated on a revolving schedule and are current to the date noted at the end of each guideline.

For additional consultation contact the UNC NCCC directly at (984) 974-3481
To transport a neonatal patient to the UNC NCCC call the Transfer Center at (800) 806-1968

* Some of the hyperlinks embedded within the documents below will not work outside the UNC Healthcare firewall

Respiratory

  • Bubble CPAP Guidelines
  • High Frequency Ventilation Guidelines
  • Inhaled Nitric Oxide Guidelines
  • Initial Ventilation Strategy for VLBW Infants
  • Mechanical Ventilation Guidelines
  • Nasal Cannula Guidelines
  • Unplanned Extubation Guidelines

Bronchopulmonary Dysplasia

  • BPD Tracheostomy Guidelines
  • Discharge of Infant with BPD Guidelines

Nutrition and Feeding

  • Amino Acid Solutions
  • Breastfeeding Contraindications including Medications
  • Breastfeeding Guidelines and Use of Donor Human Milk
  • Feeding Referrals
  • Gastrostomy Tube Guidelines
  • NICU Feeding Pathways
  • Nutrition Guidelines (Parenteral and Enteral)
  • Oral Immune Therapy
  • TPN Cycling Guidelines
  • TPN Cycling Spreadsheet

Infectious Disease

  • COVID Visitation Guidelines
  • Kaiser Neonatal Early Onset Sepsis Calculator
  • Late Onset Sepsis Antibiotic Selection
  • Management of COVID-19 Exposed Infants
  • MRSA / ORSA Guidelines
  • Peri-operative Antibiotic Use

Hematology

  • Caffeine Therapy for Apnea of Prematurity
  • Coagulation Lab Values
  • Hydrocortisone Stress Dosing
  • Hyperbilirubinemia Management Non-Hemolytic
  • Hyperbilirubinemia Management Postnatal Hemolytic
  • Transfusion of Blood Products

Medication

  • Acute Symptomatic Seizures Antiseizure Medication Pathway
  • Alprostadil (Prostin) Infusion Guidelines
  • Intravenous KCl Administration
  • Neuromuscular Blockade
  • Opioid Weaning and Narcotic Conversion
  • Systemic Postnatal Steroids for Chronic Lung Disease
  • Vitamin A Guidelines
  • Vitamin D Guidelines

Guidelines for ELBW Infants

  • ELBW Guidelines
  • Golden Hour Algorithm
  • Golden Hour Provider Role Assignments
  • Hypotension Management in ELBW Infant
  • Initial Ventilation Strategy for VLBW Infants
  • Prophylactic Hydrocortisone for ELBW Infants

Neonatal Resuscitation

  • Delayed Cord Clamping
  • ECG Monitoring in the Delivery Room
  • Management of Meconium Stained Infants
  • NRP Algorithm (8th Edition)
  • Oxygen for Neonatal Resuscitation
  • Video Taping Protocol for Resuscitation

Healthcare Maintenance

  • Carseat Screening (AAP Article)
  • Congenital Heart Disease Screening
  • Hearing Screening
  • Immunization Guidelines
  • Newborn Metabolic Screening (including SCID Algorithm)

Special Screening

  • Congenital Hip Dysplasia Screening
  • Head Ultrasounds
  • Retinopathy of Prematurity Screening and Follow-up
  • Screening for In Utero Drug Exposure
  • Thyroid Screening and Therapy

Discharge & Developmental Follow-up

  • Discharge Guidelines
  • Discharge Process Map
  • Post Discharge Nutrition
  • RSV Prophylaxis Guidelines
  • Special Infant Care Clinic Criteria

Procedural Guidelines

  • Circumcision
  • Exchange Transfusion
  • Intubation
  • Intubation Premedication
  • Procedural Pain
  • Procedural Skin Preparation

Parenteral Access

  • Long PIV (LPIV) Guidelines
  • PICC Algorithm
  • PICC Dressing Change Checklist
  • PICC Dressing Change Procedure
  • PICC Guidelines in the NCCC
  • PICC Guidelines outside the NCCC
  • Treatment of IV Infiltration or Extravasation
  • Umbilical Line Guidelines

Diagnosis Specific Guidelines

  • Acute Kidney Injury Guidelines
  • Acute Symptomatic Seizures Antiseizure Medication Pathway
  • Adrenal Insufficiency – ACTH Stimulation Test
  • Congenital Diaphragmatic Hernia Pre-Operative Management Guidelines
  • Gastroschisis Guidelines
  • HIV Clinical Guidelines
  • Hyperglycemia and the Use of Insulin
  • Hyperkalemia Guidelines
  • Hypoglycemia and the Use of Dextrose Gel in NBN
  • Hypoglycemia IVF Management Algorithm
  • Hypoxic Ischemic Encephalopathy Body Cooling Protocol
  • Myelomeningocele Guidelines
  • Necrotizing Enterocolitis (NEC) Guidelines
  • Neonatal Abstinence Syndrome – ESC Algorithm
  • Neonatal Abstinence Syndrome – ESC Epic Documentation
  • Neonatal Abstinence Syndrome – ESC Parent Handout (English)
  • Neonatal Abstinence Syndrome Guidelines (Eat, Sleep, Console)
  • Perinatal UTD – AAP Guidance
  • Persistent Pulmonary Hypertension Guidelines
  • Post-hemorrhagic Hydrocephalus Guidelines

Consults & Communication

  • Angel Eye Camera Guidelines
  • Collaborative Cardiac Care for Complex CHD
  • Do Not Resuscitate Guidelines
  • ECMO Communication and Transfer Pathway
  • Informed Consent Guidelines
  • NCCC Transfers to PICU
  • Palliative Care Guidelines

Special Protocols

  • Airway Emergency Flowchart
  • Airway Emergency Protocol
  • Documentation for Neonatal Deaths in L&D
  • Epidural Analgesia for Neonates
  • NPCC Emergency Response Plan
  • Transfer of NCCC Patients Off Unit

Prenatal Counseling

  • Consult Guidelines for Antepartum Patients
  • Counseling and Management of Extremely Preterm Infants
  • Joint OB and NCCC Antenatal Counseling for Anticipated 30-34 week Deliveries
  • Joint OB and NCCC Antenatal Counseling for Anticipated 34-36 week Deliveries
  • Joint OB and NCCC Antenatal Counseling for Anticipated Periviable Deliveries

Congenital Heart Disease (TICKER) Guidelines

  • MISSING – Teamwork to Improve Cardiac Kids End Results

We aim to improve the health and well-being of women and families across North Carolina and the U.S.

Collaborative for Maternal and Infant Health

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Campus Box 7181
Chapel Hill, NC 27599-7181
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