UNC Collaborative for Maternal & Infant Health

UNC Collaborative for Maternal & Infant Health

Improving the health of North Carolina's women and infants

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NICU Clinical Guidelines

Newborn Critical Care Center (NCCC) Clinical Guidelines

The UNC Newborn Critical Care Center (NCCC) guidelines are intended to assist providers with the clinical management of patients in the neonatal intensive care unit. These guidelines serve as reference guides and are provided only to assist providers make clinical decisions regarding the management of patients.  These guidelines do not establish a standard of care and do not substitute for the individual professional judgment necessary for each specific clinical presentation. The ultimate judgment regarding the management of a specific patient must be made by the provider and the patient, taking into account such factors as characteristics of the individual patient, healthcare resources, and regional experience with diagnostic and therapeutic modalities.  These guidelines are reviewed and updated on a revolving schedule and are current to the date noted at the end of each guideline.

For additional consultation contact the UNC NCCC directly at (984) 974-3481
To transport a neonatal patient to the UNC NCCC call the Transfer Center at (800) 806-1968

* Some of the hyperlinks embedded within the documents below will not work outside the UNC Healthcare firewall

Respiratory
  • Nasal Cannula Guidelines
  • Bubble CPAP Guidelines
  • Mechanical Ventilation Guidelines
  • High Frequency Ventilation Guidelines
  • Inhaled Nitric Oxide Guidelines
  • Initial Ventilation Strategy for VLBW Infants
Bronchopulmonary Dysplasia
  • BPD Tracheostomy Guidelines
  • Discharge of Infant with BPD Guidelines

ADDITIONAL BPD GUIDELINES COMING SOON!

Nutrition and Feeding
  • Feeding Guidelines and Pathways
  • Nutrition Guidelines (Parenteral and Enteral)
  • Amino Acid Solutions
  • Breastfeeding Guidelines and Use of Donor Human Milk
  • Breastfeeding Contraindications including Medications
  • Feeding Referrals
  • Gastrostomy Tube Guidelines
  • Oral Immune Therapy
  • TPN Cycling Guidelines
  • TPN Cycling Spreadsheet
Infectious Disease
  • Kaiser Neonatal Early Onset Sepsis Calculator
  • Late Onset Sepsis Antibiotic Selection
  • Peri-operative Antibiotic Use
  • MRSA / ORSA Guidelines
  • COVID Visitation Guidelines
  • Management of COVID-19 Exposed Infants
Hematology
  • Hyperbilirubinemia Management Non-Hemolytic
  • Hyperbilirubinemia Management Postnatal Hemolytic
  • Transfusion of Blood Products
  • Coagulation Lab Values

Medication
  • Alprostadil (Prostin) Infusion Guidelines
  • Acute Symptomatic Seizures Antiseizure Medication Pathway
  • Caffeine Therapy for Apnea of Prematurity
  • Systemic Postnatal Steroids for Chronic Lung Disease
  • Hydrocortisone Stress Dosing
  • Intravenous KCl Administration
  • Neuromuscular Blockade
  • Opioid Weaning and Narcotic Conversion
  • Vitamin A Guidelines
  • Vitamin D Guidelines

Guidelines for ELBW Infants
  • ELBW Guidelines
  • Golden Hour Algorithm
  • Golden Hour Provider Role Assignments
  • Initial Ventilation Strategy for VLBW Infants
  • Hypotension Management in ELBW Infant
  • Prophylactic Hydrocortisone for ELBW Infants

Neonatal Resuscitation
  • NRP Algorithm (8th Edition)
  • Delayed Cord Clamping
  • Oxygen for Neonatal Resuscitation
  • ECG Monitoring in the Delivery Room
  • Management of Meconium Stained Infants
  • Video Taping Protocol for Resuscitation
Healthcare Maintenance
  • Carseat Screening (AAP Article)
  • Congenital Heart Disease Screening
  • Hearing Screening
  • Immunization Guidelines
  • Newborn Metabolic Screening (including SCID Algorithm)

Special Screening
  • Congenital Hip Dysplasia Screening
  • Head Ultrasounds
  • Retinopathy of Prematurity Screening and Follow-up
  • Thyroid Screening and Therapy
  • Screening for In Utero Drug Exposure
Discharge & Developmental Follow-up
  • Discharge Guidelines
  • Discharge Process Map
  • Post Discharge Nutrition
  • Special Infant Care Clinic Criteria
  • RSV Prophylaxis Guidelines
Procedural Guidelines
  • Circumcision
  • Exchange Transfusion
  • Intubation
  • Intubation Premedication
  • Procedural Pain
  • Procedural Skin Preparation
Parenteral Access
  • PICC Guidelines in the NCCC
  • PICC Guidelines outside the NCCC
  • PICC Algorithm
  • PICC Dressing Change Checklist
  • PICC Dressing Change Procedure
  • Umbilical Line Guidelines
  • Long PIV (LPIV) Guidelines
  • Treatment of IV Infiltration or Extravasation
Diagnosis Specific Guidelines
  • Adrenal Insufficiency – ACTH Stimulation Test
  • Acute Kidney Injury Guidelines
  • Acute Symptomatic Seizures Antiseizure Medication Pathway
  • Congenital Diaphragmatic Hernia Pre-Operative Management Guidelines
  • Gastroschisis Guidelines
  • HIV Clinical Guidelines
  • Hyperglycemia and the Use of Insulin
  • Hypoglycemia and the Use of Dextrose Gel in NBN
  • Hypoglycemia IVF Management Algorithm
  • Hyperkalemia Guidelines
  • Hypoxic Ischemic Encephalopathy Body Cooling Protocol
  • Myelomeningocele Guidelines
  • Necrotizing Enterocolitis (NEC) Guidelines
  • Neonatal Abstinence Syndrome Guidelines (Eat, Sleep, Console)
    • ESC Parent Handout (English)
    • ESC Epic Documentation
    • ESC Algorithm
  • Post-hemorrhagic Hydrocephalus Guidelines
Consults & Communication
  • Angel Eye Camera Guidelines
  • Collaborative Cardiac Care for Complex CHD
  • ECMO Communication and Transfer Pathway
  • Informed Consent Guidelines
  • Palliative Care Guidelines
  • Do Not Resuscitate Guidelines
  • NCCC Transfers to PICU
Special Protocols
  • Airway Emergency Protocol
  • Airway Emergency Flowchart
  • Epidural Analgesia for Neonates
  • Documentation for Neonatal Deaths in L&D
  • Transfer of NCCC Patients Off Unit
  • NPCC Emergency Response Plan
Prenatal Counseling
  • Consult Guidelines for Antepartum Patients
  • Counseling and Management of Extremely Preterm Infants
  • Joint OB and NCCC Antenatal Counseling for Anticipated Periviable Deliveries
  • Joint OB and NCCC Antenatal Counseling for Anticipated 30-34 week Deliveries
  • Joint OB and NCCC Antenatal Counseling for Anticipated 34-36 week Deliveries
Congenital Heart Disease (TICKER) Guidelines
  • Teamwork to Improve Cardiac Kids End Results
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UNC Collaborative for Maternal and Infant Health aims to improve the health and well-being of women and families across North Carolina through community partnerships, research and clinical care innovations, and developing new approaches to complex problems.

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Campus Box 7181
Chapel Hill, NC 27599-7181

The University of North Carolina at Chapel Hill

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